Feng GE

Professor, Institute of Hydrobiology, Chinese Academy of Sciences, China

Dr. Ge is a Professor of Institute of Hydrobiology (IHB), Chinese Academy of Sciences (CAS), China. He is the awardees of Hundred Talents Program of CAS, Leader of Functional Proteomics Group of IHB and Director of Wuhan Branch of Supercomputing Center, CAS. The Ge lab’s main research interests lie in the application of state-of-the-art mass spectrometric (MS) methods for identification of proteins and for characterizing post-translational modifications in signal transduction pathways and in the analysis human and several different organisms. He used an integrated approach, involving proteomics, biochemistry, molecular biology, and cell biology to decode protein post-translational modification (PTM) networks and their functions in cyanobacteria. His laboratory demonstrates that the PTM pathways have critical roles in cellular metabolism and photosynthesis process. He is developing computational methods to extract annotated information from existing databases including genomic databases while performing searches using MS-derived data. He also used a quantitative proteomic approach to identify targets of non-coding RNA (ncRNA) that are involved in cancers. These studies are anticipated to provide proteomic insights into the molecular mechanisms of ncRNA in cancer progression. He has published over 50 papers in peer-review international journals and has lectured in many international meetings.

Recent Publications:

1: Ming-kun Yang, Yao-hua Yang, Zhuo Chen, Jia Zhang, Yan Lin, Yan Wang, Qian Xiong, Tao Li*, Feng Ge*, Donald A. Bryant, and Jin-dong Zhao. Proteogenomic analysis and global discovery of post-translational modifications in prokaryotes. Proceedings of the National Academy of Sciences of the United States of America201411152):E5633-E5642*Corresponding Author

2: Peng ZhengQian XiongYing WuYing ChenZhuo ChenJoy FlemingDing GaoLijun BiFeng Ge*Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Non-coding RNA HOTAIR in HeLa CellsMolecular & Cellular Proteomics, 2015, 14 (5) :1447-63. *Corresponding Author

3: Qian XiongJie FengSi-ting LiGui-ying ZhangZhi-xian QiaoZhuo ChenYing WuHui HuangYan LinTao Li*Feng Ge*Jin-dong Zhao*. Integrated Transcriptomic and Proteomic Analysis of the Global Response of Synechococcus sp. PCC 7002 to High Light Stress. Molecular & Cellular Proteomics2015; 14(4): 1038-53*Corresponding Author

4: Mingkun Yang, Yan Wang, Ying Chen, Zhongyi Cheng, Jing Gu, Jiaoyu Deng, Lijun Bi, Chuangbin Chen, Ran Mo, Xude Wang, and Feng Ge*. Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis H37Rv. Molecular & Cellular Proteomics201514(4): 796-811*Corresponding Author

5: Ying Chen, Li-Na Yang, Li Cheng, Shun Tu, Shu-Juan Guo, Huang-Ying Le, Qian Xiong, Ran Mo, Chong-Yang Li, Jun-Seop Jeong, Lizhi Jiang, Seth Blackshaw, Li-Jun Bi, Heng Zhu*, Sheng-Ce Tao*, and Feng Ge*. BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Molecular & Cellular Proteomics 2013;12(10):2804-19. *Corresponding Author